Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Genomic copy number alterations as predictive markers in breast cancer

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE10128: Genomic copy number alterations as predictive markers of systemic recurrence in breast cancer GSE10129: Genomic copy number alterations as predictive markers of neoadjuvant chemotherapy response in breast cancer Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Wonshik Han

PROVIDER: E-GEOD-10181 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

DNA copy number alterations and expression of relevant genes in triple-negative breast cancer.

Han Wonshik W Jung Eun-Mi EM Cho Jihyoung J Lee Jong Won JW Hwang Ki-Tae KT Yang Song-Ju SJ Kang Jason Jongho JJ Bae Ji-Yeon JY Jeon Yoon Kyung YK Park In-Ae IA Nicolau Monica M Jeffrey Stefanie S SS Noh Dong-Young DY

Genes, chromosomes & cancer 20080601 6

Triple-negative breast cancer (TNBC) is defined by a lack of expression of estrogen, progesterone, and HER2 receptors, and genetically most of them fall into the basal subgroup of breast cancer. The important issue of TNBC is poorer clinical outcome and absence of effective targeted therapy. In this study, we sought to identify DNA copy number alterations and expression of relevant genes characteristic of TNBC to discover potential therapeutic targets. Frozen tissues from 114 breast cancers were ...[more]

PMID: 18314908

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Project description:Candida albicans and Candida dubliniensis are closely related species displaying differences in virulence and genome content, therefore providing potential opportunities to identify novel C. albicans virulence genes. C. albicans gene arrays were used for comparative analysis of global gene expression in the two species in reconstituted human oral epithelium (RHE). C. albicans (SC5314) showed upregulation of hypha-specific and virulence genes within 30 min postinoculation, coinciding with rapid induction of filamentation and increased RHE damage. C. dubliniensis (CD36) showed no detectable upregulation of hypha-specific genes, grew as yeast, and caused limited RHE damage. Several genes absent or highly divergent in C. dubliniensis were upregulated in C. albicans. One such gene, SFL2 (orf19.3969), encoding a putative heat shock factor, was deleted in C. albicans. ÎÎsfl2 cells failed to filament under a range of hypha-inducing conditions and exhibited greatly reduced RHE damage, reversed by reintroduction of SFL2 into the ÎÎsfl2 strain. Moreover, SFL2 overexpression in C. albicans triggered hyphal morphogenesis. Although SFL2 deletion had no apparent effect on host survival in the murine model of systemic infection, ÎÎsfl2 strain-infected kidney tissues contained only yeast cells. These results suggest a role for SFL2 in morphogenesis and an indirect role in C. albicans pathogenesis in epithelial tissues. Global gene expression in Candida albicans SC5314 or Candida dubliniensis CD36 on reconstituted human oral epithelium (RHE) 90 min postinoculation. Gene expression on RHE was compared to gene expression on polycarbonate filter (PCF; used as RHE support matrix) 90 min postinoculation. Performed in two biological replicates with reciprocal dye swaps for each biological replicate. Gene expression of Candida cells on RHE was normalized to gene expression in reference control (PCF); log2 ratios were calculated by dividing spot intensity of experimental by that of the reference control.

Dataset Information

Genomic copy number alterations as predictive markers in breast cancer

Publications

DNA copy number alterations and expression of relevant genes in triple-negative breast cancer.

Similar Datasets

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