Genome-scale analysis of Staphylococcus aureus reveals host-specific diversification of the core genome.

ABSTRACT: Staphylococcus aureus causes disease in humans and a wide array of animals. Of note, S. aureus mastitis of ruminants, including cows, sheep and goats, results in major economic losses worldwide. Extensive variation in genome content exists among S. aureus pathogenic clones. However, the genomic variation among S. aureus strains infecting different animal species has not been well examined. To investigate variation in the genome content of human and ruminant S. aureus we carried out whole genome PCR scanning (WGPS), comparative genomic hybridizations (CGH), and directed DNA sequence analysis of strains of human, bovine, ovine, and caprine origin. Extensive variation in genome content was discovered including host- and ruminant-specific genetic loci. Ovine and caprine strains were geneticall

ORGANISM(S): Staphylococcus aureus

SUBMITTER: Dan Sturdevant 

PROVIDER: E-GEOD-10187 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress