Microarray analysis of Gene expression in limb muscles of three mouse models of Kennedy disease/SBMA

ABSTRACT: Emerging evidence implicates transcriptional dyseregulation within skeletal muscle in the pathogenesis of Kennedy disease/spinal bulbar muscular atrophy (KD/SBMA). We therefore broadly characterized gene expression in skeletal muscle of three independently generated mouse models of this disorder. The mouse models included a polyglutamine expanded (polyQ) AR knock-in model (AR113Q KI), a polyQ AR transgenic model (AR97Q Tg), and a transgenic mouse which overexpresses wild type AR solely in muscle (HSA-AR Tg). We performed microarray analysis of lower hindlimb muscles taken from these three models using high density oligonucleotide arrays. Changes in gene expression relative to wild type controls were evaluated separately in each strain. We validated our results using quantitative RT-PCR. Pa

ORGANISM(S): Mus musculus

SUBMITTER: Kaiguo Mo 

PROVIDER: E-GEOD-10190 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress