Transcription profiling by array of human MCF10A cells expressing YAP to identify the targets of the YAP oncogene

ABSTRACT: YAP is an oncogene and an inducer of Epithelial-to-Mesenchymal Transition (EMT). We used microarrays to detail the global program of gene expression to identify YAP target genes. PUBLICATION ABSTRACT:; The Hippo pathway defines a novel signaling cascade regulating cell proliferation and survival in Drosophila, which involves the negative regulation of the transcriptional coactivator Yorkie by the kinases Hippo and Warts. We have recently shown that the human ortholog of Yorkie, YAP, maps to a minimal amplification locus in mouse and human cancers, and that it mediates dramatic transforming activity in MCF10A primary mammary epithelial cells. Here we show that LATS proteins (mammalian orthologs of Warts) interact directly with YAP in mammalian cells and that ectopic expression of LATS1, bu

ORGANISM(S): Homo sapiens

SUBMITTER: Daniel Haber 

PROVIDER: E-GEOD-10196 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress