Glycogen Accumulation in Chlamydia trachomatis is Controlled by its Plasmid Through Regulation of glgA

ABSTRACT: C. trachomatis possess a cryptic 7.5 kb plasmid of unknown function. Here we describe a comprehensive molecular and biological characterization of the naturally occurring plasmidless human Chlamydia trachomatis strain L2 (25667R). We found that despite minimal chromosomal polymorphisms the LGV L2 (25667R) strain was indistinguishable from the L2 (434) plasmid positive strain in its in vitro infectivity characteristics such as growth kinetics, plaquing efficiency, and plaque size. The primary in vitro phenotypic differences between L2 (434) and L2 (25667R) were the accumulation of glycogen granules in the inclusion matrix and the lack of the typical intra-inclusion Brownian-like movement characteristic of C. trachomatis strains. Conversely, we observed a marked difference between the two

ORGANISM(S): Chlamydia trachomatis

SUBMITTER: Neysha Martinez-Orengo 

PROVIDER: E-GEOD-10199 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress