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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Hemocyte minus versus hemocyte plus drosophila embryos

ABSTRACT: Drosophila embryos that were lacking the hemocyte lineage were compared to wild-type embryos. Keywords: genetic modification Wild-type drosophila embryos were compared to serpent mutant embryos.

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Mark Winfield

PROVIDER: E-GEOD-10208 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene induction following wounding of wild-type versus macrophage-deficient Drosophila embryos.

Stramer Brian B Winfield Mark M Shaw Tanya T Millard Thomas H TH Woolner Sarah S Martin Paul P

EMBO reports 20080314 5

By using a microarray screen to compare gene responses after sterile laser wounding of wild-type and 'macrophageless' serpent mutant Drosophila embryos, we show the wound-induced programmes that are independent of a pathogenic response and distinguish which of the genes are macrophage dependent. The evolutionarily conserved nature of this response is highlighted by our finding that one such new inflammation-associated gene, growth arrest and DNA damage-inducible gene 45 (GADD45), is upregulated ...[more]

PMID: 18344972

Similar Datasets

Expression study of 'hemocyte minus vs hemocyte plus, and wounded vs unwounded hemocyte deficient' drosophila embryos

Project description:This SuperSeries is composed of the following subset Series: GSE10207: wounded versus nonwounded drosophila embryos GSE10208: hemocyte minus versus hemocyte plus drosophila embryos GSE10209: wounded vs unwounded hemocyte deficient embryos Keywords: SuperSeries Refer to individual Series

2010-05-22 | E-GEOD-10225 | biostudies-arrayexpress

wounded vs unwounded hemocyte deficient embryos

Project description:Wounded versus unwounded embryos lacking the hemocyte lineage were compared. Keywords: wounded vs unwounded srp mutant embryos Serpent mutant embryos were wounded by laser ablation and compared to unwounded.

2010-05-22 | E-GEOD-10209 | biostudies-arrayexpress

wounded versus nonwounded drosophila embryos

Project description:Elucidation of the wound response genes in Drosophila embryos Keywords: response to wounding wild-type drosophila embryos were wounded by laser ablation and compared to unwounded embryos.

2008-04-01 | E-GEOD-10207 | biostudies-arrayexpress

hemocyte minus versus hemocyte plus drosophila embryos

Project description:Drosophila embryos that were lacking the hemocyte lineage were compared to wild-type embryos. Keywords: genetic modification

2008-04-01 | GSE10208 | GEO

Skeletal muscle cell fusion time course

Project description:Time course experiment of healthy primary skeletal muscle cells KM109, KM108 and HPP4 after initiation of fusion This SuperSeries is composed of the following subset Series: GSE884: KM109 GSE895: KM108_cDNA GSE896: HPP4_cDNA

2004-02-11 | E-GEOD-906 | biostudies-arrayexpress

Characterization of human embryonic stem cells with features of neoplastic progression

Project description:Cultured human embryonic stem (hES) cells can acquire genetic and epigenetic changes that make them vulnerable to transformation. As hES cells with cancer-cell characteristics share properties with normal hES cells, such as self-renewal, teratoma formation and the expression of pluripotency markers, they may be misconstrued as superior hES cells with enhanced âstemnessâ. We characterize two variant hES cell lines (v-hESC-1 and v-hESC-2) that express pluripotency markers at high levels and do not harbor chromosomal abnormalities by standard cytogenetic measures. We show that the two lines possess some features of neoplastic progression, including a high proliferative capacity, growth-factor independence, a 9- to 20-fold increase in frequency of tumor initiating cells, niche independence and aberrant lineage specification, although they are not malignant. Array comparative genomic hybridization revealed an amplification at 20q11.1-11.2 in v-hESC-1 and a deletion at 5q34a-5q34b;5q3 and a mosaic gain of chromosome 12 in v-hESC-2. These results emphasize the need for functional characterization to distinguish partially transformed and normal hES cells. Custom oligonucleotide array gene expression analysis was performed on total RNA from low passage normal and variant human embryonic stem cell (hESC) lines, all cultured in our laboratory under the same conditions. Furthermore, array-based comparative genomic hybridization was also performed on the normal and variant hESC lines. v-hESC-1 and v-hESC-2 represent two independent lines that display neoplastic characteristics with distinctive copy number alterations. v-hESC-1_A2B5 represents neural precursor cultures differentiated from variant hES cells. GSM349016-GSM349022: Gene expression analysis GSM351500-GSM351511: aCGH analysis

2010-06-24 | E-GEOD-13995 | biostudies-arrayexpress

Effect of HdIV or MdBV injection on the Spodoptera frugiperda hemocyte transcriptome

Project description:Comparison of the effects of 2 polydnaviruses (HdIV vs MdBV) injection on L5 Spodoptera frugiperda larvae hemocytes transcriptome. The experimental design is as follows: 3 biological replicates with dye swap. Each treatment (HdIV or MdBv) is compared to control treatment (PBS).

2011-04-05 | E-GEOD-16775 | biostudies-arrayexpress

wounded vs unwounded hemocyte deficient embryos

Project description:Wounded versus unwounded embryos lacking the hemocyte lineage were compared. Keywords: wounded vs unwounded srp mutant embryos

2008-04-01 | GSE10209 | GEO

hepatocellular carcinoma vs. corresponding noncancerous liver or normal liver

Project description:Hepatocellular carcinoma (HCC) remains a major health problem worldwide, and HCC patients have a poor prognostic outcome. In this study, we systematically disclose mechanisms of hepatocarcinogenesis, and also effectively identify and validate novel anticancer targets in HCCs. Keywords: disease state analysis total 58 cDNA microarrays, all experiment samples are hepatocellular carcinoma. RNAs from 33 corresponding noncancerous livers and 5 normal livers were used as the reference, respectively. The tumor samples were labeled with Cy5-dUTP.The nontumor samples were labeled with Cy3-dUTP.

2009-01-06 | E-GEOD-4108 | biostudies-arrayexpress

Effect of HdIV or MdBV injection on the Spodoptera frugiperda hemocyte and fat body transcriptomes

Project description:This SuperSeries is composed of the following subset Series: GSE16775: Effect of HdIV or MdBV injection on the Spodoptera frugiperda hemocyte transcriptome GSE16776: Effect of HdIV or MdBV injection on the Spodoptera frugiperda fat body transcriptome Refer to individual Series

2011-04-05 | E-GEOD-17293 | biostudies-arrayexpress

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