Transcription profiling of human breast cancers reveals bisphenol A induces a profile of tumor aggressiveness in high-risk cells of breast cancer patients

ABSTRACT: Breast cancer outcome is highly variable. Whether inadvertent exposure to environmental xenobiotics evokes a biological response promoting cancer aggressiveness and a higher probability of tumor recurrence remains unknown. To determine specific molecular alterations, which arise in high-risk breast tissue in the presence of the ubiquitous xenoestrogen, bisphenol A (BPA), we employed non-malignant random periareolar fine needle aspirates (RPFNA) in a novel functional assay. Early events induced by BPA in epithelial-stromal cocultures derived from the contralateral tissue of breast cancer patients included gene expression patterns, which facilitate apoptosis evasion, endurance of microenvironmental stress, and cell cycle deregulation without a detectable increase in cell number. This BPA res

ORGANISM(S): Homo sapiens

SUBMITTER: Junhee Seok 

PROVIDER: E-GEOD-10270 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress