Transcription profiling of mouse strains for eQTL CNV Analysis

ABSTRACT: Background; Haplotype association mapping is a recently developed method that can be used to identify expression Quantitative Trait Loci (eQTLs). The underlying genomic structure of the haplotype can be defined by single nucleotide polymorphisms (SNPs), variable number tandem repeats (VNTRs) and copy number variations (CNVs). Microarray genotyping platforms are able to interrogate all three genomic polymorphisms simultaneously. Combined with gene expression data, these data allow for the elucidation of sites responsible for the regulation of transcription. Results; Thirty three inbred strains were genotyped on a microarray platform to assess possible contributions of polymorphic regions to gene expression. Over one hundred million statistical correlations were made between probe perfo

ORGANISM(S): Mus musculus

SUBMITTER: Mathew Pletcher 

PROVIDER: E-GEOD-10377 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress