Co-activator function of RIP140 for NFκB/p65-dependent cytokine gene

ABSTRACT: High- and low-grade inflammatory responses represent a hallmark of numerous pathologies such as sepsis and bacterial infection or insulin resistance and obesity, respectively. Here we describe an unexpected co-activator function of receptor interacting protein (RIP) 140 for nuclear factor (NF) kB, a master transcriptional regulator of inflammation in multiple tissues. Genetic as well as acute deficiency of RIP140, which has been characterized as a co-repressor of various nuclear receptors on metabolic target genes, led to the inhibition of the proinflammatory program in macrophages, mediated by RIP140’s direct impact on cytokine gene promoter activity. Intriguingly, RIP140’s co-activator function in this setting was found to rely on direct protein-protein interactions with the NFκB su

ORGANISM(S): Mus musculus

SUBMITTER: Thomas Hofmann 

PROVIDER: E-GEOD-10386 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress