Transcription profiling of rat - triazole antifungal toxicogenomics: rat_repro_Liver

ABSTRACT: The modes of triazole reproductive toxicity have been characterized by an observed increased in serum testosterone and reduced insemination and fertility indices. The key events involved in the disruption in testosterone homeostasis and reduced fertility remain unclear. Gene expression analysis was conducted on liver and testis from Wistar Han IGS rats fed myclobutanil (M: 500, 2000 ppm), propiconazole (P: 500, 2500 ppm), or triadimefon (T: 500, 1800 ppm) from gestation day six to postnatal day 92. Pathway-based analysis highlighted key biological processes affected by all three triazoles in the liver including fatty acid catabolism, steroid metabolism, and xenobiotic metabolism. Triadimefon induced a distinctive expression profile of genes involved in liver sterol biosynthesis. There were

ORGANISM(S): Rattus norvegicus

SUBMITTER: David Dix 

PROVIDER: E-GEOD-10411 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress