Novartis 12 Strain Diet Sex Survey

ABSTRACT: High-fat diets are associated with increased obesity and metabolic disease in mice and humans. Here we used analysis of variance (ANOVA) to scrutinize a microarray data set consisting of 10 inbred strains of mice from both sexes fed atherogenic high-fat and control chow diets. An overall F-test was applied to the 40 unique groups of strain-diet-sex to identify 15,288 genes with altered transcription. Bootstrapping k-means clustering separated these changes into four strain-dependent expression patterns, including two sex-related profiles and two diet-related profiles. Sex-induced effects correspond to secretion (males) or fat and energy metabolism (females), whereas diet-induced changes relate to neurological processes (chow) or immune response (high-fat). The full set of pairwise contrast

ORGANISM(S): Mus musculus

SUBMITTER: Keith Shockley 

PROVIDER: E-GEOD-10493 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress