Transcription profiling of mouse Bax null versus NGF-Bax double null animals

ABSTRACT: We report that developmental competition between sympathetic neurons for survival is critically dependent on a sensitization process initiated by target innervation and mediated by a series of feedback loops. Target-derived nerve growth factor (NGF) promoted expression of its receptor TrkA in neurons and prolonged TrkA-mediated signals. NGF also controlled expression of brain derived neurotrophic factor (BDNF) and neurotrophin-4 (NT4), which, through the receptor p75, can kill neighboring neurons with low retrograde NGFâ??TrkA signaling whereas neurons with high NGFâ??TrkA signaling are protected. Perturbation of any of these feedback loops disrupts the dynamics of competition. We suggest that three target-initiated events are essential for rapid and robust competition between neurons

ORGANISM(S): Mus musculus

SUBMITTER: David Ginty 

PROVIDER: E-GEOD-10498 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress