Genomic alterations and gene expression in primary diffuse large B cell lymphomas of immune privileged sites

ABSTRACT: Primary diffuse large B cell lymphomas of different immune-privileged sites (IP-DLBCL) share many clinical and biological features, such as a relatively poor prognosis, preferential dissemination to other immune-privileged sites and deletion of the HLA region, which suggests that IP-DLBCL represents a separate entity. To further investigate the nature of IP-DLBCL, we investigated site-specific genomic aberrations in 16 testicular, 9 central nervous system (CNS) and 15 nodal DLBCL using array-CGH. We also determined minimal common regions of gain and loss. Using robust algorithms, the array-CGH data were combined with gene expression data to explore pathways deregulated by chromosomal aberrations. Keywords: comparative genomic hybridisation, gene expression, tumor type comparison Whole tiss

ORGANISM(S): Homo sapiens

SUBMITTER: Marije Booman 

PROVIDER: E-GEOD-10524 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress