Conservation of small RNA pathways in platypus

ABSTRACT: Small RNA pathways play evolutionarily conserved roles in gene regulation and in defense from pathogenic and parasitic nucleic acids. The character and expression patterns of small RNAs show conservation throughout animal lineages, but specific animal clades also show variations on these recurring themes, including species-specific small RNAs. The monotremes, with only platypus and four species of echidna as extant members, represent the basal branch of the mammalian lineage. Here, we examine the small RNA pathways of monotremes by deep sequencing of six platypus and echidna tissues. We find that highly conserved microRNA species display their signature tissue-specific expression patterns. In addition, we find a large rapidly-evolving cluster of miRNAs on platypus chromosome X1 which is u

ORGANISM(S): Tachyglossus aculeatus

SUBMITTER: ravi Sachidanandam 

PROVIDER: E-GEOD-10571 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress