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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mice mutant for prCAD vs BALBC after dark adaption or retinal damage to investigate the genomic response to retinal disease and injury.

ABSTRACT: This SuperSeries is composed of the following subset Series:; GSE10528: The retinal transcriptional response to light damage; GSE10535: Retinal transcripts level alteration in the prCAD -/- mouse, a model for retinal degeneration Experiment Overall Design: Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Amir Rattner

PROVIDER: E-GEOD-10577 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The genomic response to retinal disease and injury: evidence for endothelin signaling from photoreceptors to glia.

Rattner Amir A Nathans Jeremy J

The Journal of neuroscience : the official journal of the Society for Neuroscience 20050501 18

Regardless of proximal cause, photoreceptor injury or disease almost invariably leads to the activation of Muller cells, the principal glial cells in the retina. This observation implies the existence of signaling systems that inform Muller cells of the health status of photoreceptors. It further suggests that diverse types of photoreceptor damage elicit a limited range of biochemical responses. Using the mouse retina, we show by microarray, RNA blot, and in situ hybridization that the genomic r ...[more]

PMID: 15872101

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Transcription profiling of prCAD -/- mouse, a mouse model for retinal degeneration

Project description:This experiment was designed to identify transcripts that exhibit changes in abundance in the context of retinal degeneration by comparing transcript levels in adult wild type and prCAD -/- mouse retinas. Experiment Overall Design: Retinas were dissected from ~4 weeks old mice. Retinas from 3 prCAD knockout mice or wild type 129 mice were pooled for each sample and 3 replicate of wild type and mutant samples were analysed.

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