Transcription profiling of mouse cecal mucosa AFTER infection WITH Salmonella serotype Typhimurium

ABSTRACT: Salmonella enterica serotype Typhimurium causes an acute inflammatory reaction in the cecum of streptomycin pre-treated mice. We determined global changes in gene expression elicited by serotype Typhimurium in the cecal mucosa. The gene expression profile was dominated by T cell derived cytokines and genes whose expression is known to be induced by these cytokines. Markedly increased mRNA levels of interferon (IFN) , interleukin (IL) 22 and IL-17 were detected by quantitative real-time PCR. Furthermore, mRNA levels of genes whose expression is induced by IFN, IL-22 or IL-17, including macrophage inflammatory protein (MIP)-2, inducible nitric oxide synthase (iNOS), lipocalin-2, MIP-1, MIP-1, and keratinocyte-derived cytokine (KC), were also markedly increased. To assess the impo

ORGANISM(S): Mus musculus

SUBMITTER: Michael George 

PROVIDER: E-GEOD-10594 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress