Transcription profiling of human epithelial cells laser captured FROM intestinal mucosa FROM 4 individuals undergoing surgery FOR colon cancer, bowel obstruction, OR other non-inflammatory conditions

ABSTRACT: The small intestinal epithelium mediates vital functions of nutrient absorption and host defense. The spatial organization of the epithelial cells along the crypt-villus axis segregates them into regions of specialized function. However, many of the mechanisms governing intestinal epithelial cell migration and the coordination of interactions with adjacent cells and the extracellular matrix are not fully understood. We have evaluated in vivo gene expression patterns of ileal epithelial cells in healthy human subjects, isolated by laser capture microdissection from either the villus epithelial or crypt cell regions of the small intestinal mucosa. Expression profiles in villus epithelium and Paneth cell lineages were determined by quantitative real-time PCR, DNA microarray, and immunohistoch

ORGANISM(S): Homo sapiens

SUBMITTER: Michael George 

PROVIDER: E-GEOD-10629 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress