Transcription profiling of mouse kidney from Aquaporin-11 knockout effect

ABSTRACT: Aquaporin-11 (AQP11), a new member of the aquaporin family, is localized in the endoplasmic reticulum (ER). Aqp11–/– mice neonatally suffer from polycystic kidneys derived from the proximal tubule. Its onset is proceeded by the vacuolization of ER. However, the mechanism for the formation of vacuoles and the development of cysts remain to be clarified. Here, we show that Aqp11–/– mice and polycystic kidney disease animals share a common pathogenic mechanism of cyst formation. Experiment Overall Design: Aqp11+/– mice, originally generated in a 129/SvEvBrd background (4), were back-crossed 10–11 times to a C57/BL6 background. Heterozygous mice were interbred to obtain knockout (Aqp11–/–) and wild-type littermates (Aqp11+/+). The genotypes of offsprings were analyzed by

ORGANISM(S): Mus musculus

SUBMITTER: Shinji Okada 

PROVIDER: E-GEOD-10634 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress