Identification of Differential Gene Expression During Transition of Bovine Corpus Luteum from Early To Mid–Phase.

ABSTRACT: Prostaglandin F2 alpha (PGF2alpha) brings about regression of the bovine corpus luteum (CL). This luteolytic property of PGF2alpha is used in the beef and dairy cattle to synchronize estrus. A limitation of this protocol is an insensitivity of the early CL to luteolytic actions of PGF2alpha. The mechanisms underlying luteal sensitivity (LS) are poorly understood. The early CL has maximum number of PGF2alpha receptors; therefore differences in signaling events might be responsible for LS. Hence differential gene expression at two developmental stages, days 4 (D-4) and 10 (D-10) post estrus, might account for differences in signal transduction pathways associated with LS. This possibility was examined in these studies. Microarray analysis (n=3 per stage) identified 167 genes that were differ

ORGANISM(S): Bos taurus

SUBMITTER: MADHUSUDHAN GORAVANAHALLY 

PROVIDER: E-GEOD-10662 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress