Transcription profiling of mouse mdr1a-/- a model of IBD response to dietary curcumin and rutin on colonic inflammation

ABSTRACT: Damage of the intestinal epithelial barrier by xenobiotics or reactive oxygen species and a dysregulated immune response are both factors involved in the pathogenesis of inflammatory bowel diseases (IBD). Curcumin and rutin are polyphenolic compounds known to have anti-oxidant and anti-inflammatory activities, but their mechanism(s) of action are yet to be fully elucidated. Mdr1a-/- mice spontaneously develop intestinal inflammation, predominantly in the colon, with pathology similar to IBD, so this mouse model is relevant for studying diet-gene interactions and potential effects of foods on remission or development of IBD. This study tested whether the addition of curcumin or rutin to the diet would alleviate colonic inflammation in mdr1a-/- mice. Using whole-genome microarrays, the effec

ORGANISM(S): Mus musculus

SUBMITTER: Katia Nones 

PROVIDER: E-GEOD-10684 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress