Transcription profiling of mouse ervical and skin tissues from HPV 16 E6 transgenic animals

ABSTRACT: Background; The in vivo properties of HR-HPV E6 and E7 oncoproteins have been previously evaluated through the generation and characterization of HPV transgenic mouse strains. Although K14E6 transgenic mice develop spontaneous tumors of the skin epithelium, no spontaneous reproductive tract malignancies arise, unless the transgenic mice were treated chronically with 17β-estradiol. Taken together, these findings suggest that E6 performs critical functions in normal adult cervix and skin, highlighting the need to define E6-controlled transcriptional programs in these tissues. We evaluated the different expression profile of 14,000 genes in skin or cervix from young K14E6 transgenic mice compared with corresponding tissues from non-transgenic (FVB) mice. Result; Microarray analysis identifie

ORGANISM(S): Mus musculus

SUBMITTER: Alfredo Hidalgo-Miranda 

PROVIDER: E-GEOD-10702 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress