Altered gene expression in the brain and liver of female fathead minnows exposed to fadrozole

ABSTRACT: The fathead minnow (Pimephales promelas) is a small fish species widely used for ecotoxicology research and regulatory testing in North America. This study used a 2000 gene oligonucleotide microarray to evaluate the effects of the aromatase inhibitor, fadrozole, on gene expression in the liver and brain tissue of exposed females. Reproductive measures, plasma vitellogenin, and gene expression data for the brain isoform of aromatase (CYP19B), vitellogenin precursors, and transferrin all provided evidence supporting the efficacy of the fadrozole exposure. Unsupervised analysis of the microarray results identified 20 genes in brain and 41 in liver as significantly up-regulated and 7 genes in brain and around 45 in liver as significantly down-regulated. Differentially expressed genes were

ORGANISM(S): Pimephales promelas

SUBMITTER: Patrick Larkin 

PROVIDER: E-GEOD-10722 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress