Transcription profiling of human parental MM6 cell response to lipoloysaccharide and phorbal ester

ABSTRACT: Parental MM6 cells, as an additional control, were treated with LPS and PMA. Genes affected by the treatments were identified. HIV-1 is dependent upon cellular co-factors to mediate its replication cycle in CD4+ T cells and macrophages, the two major cell types infected by the virus in vivo. One critical co-factor is Cyclin T1, a subunit of a general RNA polymerase II elongation factor known as P-TEFb. Cyclin T1 is targeted directly by the viral Tat protein to activate proviral transcription. Cyclin T1 is up-regulated when resting CD4+ T cells are activated and during macrophage differentiation or activation, conditions that are also necessary for high levels of HIV-1 replication. Because Cyclin T1 is a subunit of a transcription factor, the up-regulation of Cyclin T1 in these cells re

ORGANISM(S): Homo sapiens

SUBMITTER: Andrew Rice 

PROVIDER: E-GEOD-10739 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress