Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling by array of human patients with acute myeloid leukemia and chemotherapy-induced oral mucositis

ABSTRACT: Chemotherapy may cause DNA damage within the oral mucosa of cancer patients leading to mucositis, a dose-limiting side effect for effective cancer treatment. We used whole genome gene expression analysis to identify cellular damage to the mucosal tissue occuring two days post induction chemotherapy and identified gene expression patterns that may or may not be predictive of oral mucositis. Experiment Overall Design: Punch buccal biopsies from healthy controls (HC, samples BRENC1, BRENC2, BRENC3, n=3) and five AML patients pre-chemotherapy (Pre-C, samples BREN11, BREN21, BREN41, BREN51, n=4) and (Post-C, samples BREN22, BREN32, BREN42, BREN52, n=4)(Ntotal=11) gave suitable RNA integrity to perform microarray analysis. Samples Pre-C:BREN31 and post-C:BREN12 were not suitable for microarray analysis. Human Genome U133 Plus 2.0 Array (Affymetrix, Santa Clara, CA) was used to conduct gene expression profiling.

ORGANISM(S): Homo sapiens

SUBMITTER: Jean-Luc Mougeot 

PROVIDER: E-GEOD-10746 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Microarray analyses of oral punch biopsies from acute myeloid leukemia (AML) patients treated with chemotherapy.

Mougeot Jean-Luc C JL   Bahrani-Mougeot Farah K FK   Lockhart Peter B PB   Brennan Michael T MT  

Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20110908 4

<h4>Objective</h4>Understanding the pathogenesis of chemotherapy-induced oral mucositis (CIOM) is vital to develop therapies for this common, dose-limiting side effect of cancer treatment. We investigated molecular events in CIOM from buccal mucosa tissue collected before and 2 days after chemotherapy from patients with acute myeloid leukemia (AML) and healthy controls by microarray analysis.<h4>Methods</h4>Microarray analysis was performed using Human Genome U133 Plus 2.0 Array on buccal mucosa  ...[more]

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