Transcription profiling of rat samples response to dioxins (TCDD) to study the conserved transcriptional response of rat and mouse, see related set E-GEOD-10769 for mouse data

ABSTRACT: Background; Mouse and rat models are mainstays in pharmacology, toxicology and drug development – but differences between strains and between species complicate data interpretation and application to human health. Dioxin-like polyhalogenated aromatic hydrocarbons represent a major class of environmentally and economically relevant toxicants. In mammals dioxin exposure leads to a broad spectrum of adverse affects, including hepatotoxicity of varying severity. Several studies have shown that dioxins extensively alter hepatic mRNA levels. Surprisingly, though, analysis of a limited portion of the transcriptome revealed that rat and mouse responses diverge greatly (Boverhof et al. Toxicol Sci 94:398–416, 2006). Results; We employed oligonucleotide arrays to compare the response of 8,125 ra

ORGANISM(S): Rattus norvegicus

SUBMITTER: Paul Boutros 

PROVIDER: E-GEOD-10770 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress