Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human primary lung adenocarcinomas

ABSTRACT: We have investigated whether the early dissemination of tumor cells into bone marrow is associated with a specific molecular pattern in primary lung cancer Experiment Overall Design: two groups of primary lung adenocarcinomas were compared differentiating in the metastatic potential

ORGANISM(S): Homo sapiens

SUBMITTER: Thomas Streichert 

PROVIDER: E-GEOD-10799 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Genomic profiles associated with early micrometastasis in lung cancer: relevance of 4q deletion.

Wrage Michaela M   Ruosaari Salla S   Eijk Paul P PP   Kaifi Jussuf T JT   Hollmén Jaakko J   Yekebas Emre F EF   Izbicki Jakob R JR   Brakenhoff Ruud H RH   Streichert Thomas T   Riethdorf Sabine S   Glatzel Markus M   Ylstra Bauke B   Pantel Klaus K   Wikman Harriet H  

Clinical cancer research : an official journal of the American Association for Cancer Research 20090210 5

<h4>Purpose</h4>Bone marrow is a common homing organ for early disseminated tumor cells (DTC) and their presence can predict the subsequent occurrence of overt metastasis and survival in lung cancer. It is still unclear whether the shedding of DTC from the primary tumor is a random process or a selective release driven by a specific genomic pattern.<h4>Experimental design</h4>DTCs were identified in bone marrow from lung cancer patients by an immunocytochemical cytokeratin assay. Genomic aberrat  ...[more]

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