Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse uterine horns from Hoxa-10+/+ and Hoxa-10-/- littermates

ABSTRACT: Female mice used were SvJ/129, 10-16 weeks of age; Hoxa-10+/+ and Hoxa-10-/- littermates were used in parallel experiments. 14 days after ovariectomy, mice were injected subcutaneously with progesterone dissolved in sesame oil (Sigma; 0.2mg/0.1mL/mouse), followed by sacrifice and removal of uterine horns at 6 hours after injection. 8 uterine horns from 4 mice were pooled to form one sample. Total RNA preparation, cRNA labeling and hybridization were performed according to recommendations by Affymetrix. The 6 samples were obtained and processed in two batches: (1: GSM3047 and GSM3041), and (2: GSM3048, GSM3049, GSM3042, and GSM3043).

ORGANISM(S): Mus musculus

SUBMITTER: Richard Maas 

PROVIDER: E-GEOD-108 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Gene expression profiling reveals progesterone-mediated cell cycle and immunoregulatory roles of Hoxa-10 in the preimplantation uterus.

Yao Mylene W M MW   Lim Hyunjung H   Schust Daniel J DJ   Choe Sung E SE   Farago Anna A   Ding Yueyun Y   Michaud Sebastien S   Church George M GM   Maas Richard L RL  

Molecular endocrinology (Baltimore, Md.) 20030109 4

Human infertility and recurrent pregnancy loss caused by implantation defects are poorly understood. Hoxa-10-deficient female mice have severe infertility and recurrent pregnancy loss due to defective uterine implantation. Gene expression profiling experiments reveal that Hoxa-10 is an important regulator of two critical events in implantation: stromal cell proliferation and local immunosuppression. At the time of implantation, Hoxa-10 mediates the progesterone-stimulated proliferation of uterin  ...[more]

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