The in vitro expanded CD8+ T cells and its controls

ABSTRACT: CD8+ NKT cells are naturally occurring but rare T cells that express both T cell and natural killer (NK) cell markers. These cells may play key roles in establishing tolerance to self antigens; however, the mechanism of action and the molecular profiles of these cells are poorly characterized due to their extremely low frequencies. We developed a highly efficient in vitro conversion/expansion protocol for such cells and extensively characterized their functional and molecular phenotypes using a variety of genomic and immunological techniques. We used microarrays to elucidate the molecular mechanisms underlying the suppression function of the converted CD8+ NKT cells. Keywords: Cell type comparison To identify candidate genes that might be related to the suppressive activity, the CD8+ NKT

ORGANISM(S): Mus musculus

SUBMITTER: Jin-Xiong She 

PROVIDER: E-GEOD-10813 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress