Tumor-specific Th17-polarized cells eradicate large established melanoma

ABSTRACT: CD4+ T cells can differentiate into multiple effector subsets but the potential roles of these subsets in anti-tumor immunity have not been fully explored. We sought to study the impact of CD4+ T cell polarization on efficacy of tumor rejection in a model closely mimicking human disease where the target antigens are often non-mutated tissue differentiation self-antigens. We generated a new transgenic mouse model in which CD4+ T cells recognize a novel epitope in tyrosinase-related protein 1 (TRP-1), an antigen that is expressed by normal melanocytes and B16 murine melanoma. We found that cells could be robustly polarized into Th0, Th1 and Th17 subtypes in vitro, as evidenced by cytokine, chemokine, and adhesion molecule profiles as well as by surface markers, suggesting the potential for d

ORGANISM(S): Mus musculus

SUBMITTER: Pawel Muranski 

PROVIDER: E-GEOD-10814 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress