DK5653/DK1622 Vegetative

ABSTRACT: Isovaleryl-CoA (IV-CoA) is usually derived from the degradation of leucine using the Bkd (branched-chain ketoacid dehydrogenase) complex. In myxobacteria we have previously identified an alternative pathway for IV-CoA formation that branches from the well-known mevalonate dependent isoprenoid biosynthesis pathway and we could already identify the 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase (MvaS) to be involved in this pathway in Myxococcus xanthus which is induced under leucine limiting conditions like in mutants impaired in leucine degradation or during myxobacterial fruiting body formation. Here we show that proteins involved in leucine degradation are also involved in the alternative IV-CoA biosynthesis by catalyzing the reverse reactions of that used in leucine degradation. More

ORGANISM(S): Myxococcus xanthus

SUBMITTER: Helge Bode 

PROVIDER: E-GEOD-10818 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress