Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Michael Lisanti
PROVIDER: E-GEOD-10848 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Augustus Ayanna S AS Buchanan Jonathan J Addya Sankar S Rengo Giuseppe G Pestell Richard G RG Fortina Paolo P Koch Walter J WJ Bensadoun Andre A Abel E Dale ED Lisanti Michael P MP
American journal of physiology. Heart and circulatory physiology 20080613 2
Caveolin-3 (Cav3), the primary protein component of caveolae in muscle cells, regulates numerous signaling pathways including insulin receptor signaling and facilitates free fatty acid (FA) uptake by interacting with several FA transport proteins. We previously reported that Cav3 knockout mice (Cav3KO) develop cardiac hypertrophy with diminished contractile function; however, the effects of Cav3 gene ablation on cardiac substrate utilization are unknown. The present study revealed that the uptak ...[more]