Role of SRF in activity-regulated transcription in the striatum of the brain

ABSTRACT: Ablation of the Srf gene in dopaminoceptive neurons of the brain was performed using the Cre/loxP system, with the recombinase expressed from a BAC-derived Drd1a promoter. Our goal was to analyze how loss of SRF will affect acitivity-regulated transcription induced by strong stimulation, i.e. cocaine. Keywords: Treatment x Genotype Animals were injected i.p. with either 25 mg/kg cocaine or saline and sacrificed after one hour by cervical dislocation. Expression profiling was performed using total RNA isolated from the striatum.

ORGANISM(S): Mus musculus

SUBMITTER: Jan Rodriguez Parkitna 

PROVIDER: E-GEOD-10870 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress