H3K9acetyl ChIP on chip for integrative epigenomic study in leukemia samples

ABSTRACT: The molecular heterogeneity of acute leukemias and other tumors constitutes a major obstacle towards understanding disease pathogenesis and developing new targeted-therapies. Aberrant gene regulation is a hallmark of cancer and plays a central role in determining tumor phenotype. We predicted that integration of different genome-wide epigenetic regulatory marks along with gene expression levels would provide greater power in capturing biological differences between leukemia subtypes. Gene expression, cytosine methylation and histone H3 lysine 9 (H3K9) acetylation were measured using high-density oligonucleotide microarrays in primary human acute myeloid leukemia (AML) and acute lymphocytic leukemia (ALL) specimens. We found that DNA methylation and H3K9 acetylation distinguished these leu

ORGANISM(S): Homo sapiens

SUBMITTER: Maria Figueroa 

PROVIDER: E-GEOD-10887 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress