Altered genes expression profile of Rep2 mutants in Fission Yeast upon HU treatment.
Ontology highlight
ABSTRACT:
ORGANISM(S): Schizosaccharomyces pombe
SUBMITTER: Jianhua Liu
PROVIDER: E-GEOD-10901 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
A Cds1-mediated checkpoint protects the MBF activator Rep2 from ubiquitination by anaphase-promoting complex/cyclosome-Ste9 at S-phase arrest in fission yeast.
Chu Zhaoqing Z Eshaghi Majid M Poon Suk Yean SY Liu Jianhua J
Molecular and cellular biology 20090713 18
Transcription of the MluI cell cycle box (MCB) motif-containing genes at G(1) phase is regulated by the MCB-binding factors (MBF) (also called DSC1) in Schizosaccharomyces pombe. Upon S-phase arrest, the MBF transcriptional activity is induced through the accumulation of the MBF activator Rep2. In this study, we show that the turnover of Rep2 is attributable to ubiquitin-mediated proteolysis. Levels of Rep2 oscillate during the cell cycle, with a peak at G(1) phase, coincident with the MBF activ ...[more]
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