Transcription profiling of mouse leukemia (HSC) haematopoietic stem cells expressing BCR/ABL

ABSTRACT: The BCR-ABL oncogene, generated by Philadelphia chromosome, is present in about 95% human Chronic myeloid leukemia (CML) and 20~30% acute lymphoblastic leukemia (ALL). One of BCR-ABL isoforms, P210, is more often detected in CML and ALL patients. Although BCR-ABL kinase inhibitors are effective in controlling the diseases, they do not provide cure due to the development of drug resistance and the insensitivity of leukemia stem cells to these drugs. Identification of new therapeutic targets is critical. To identify potential target against leukemia stem cells, we studied gene expression in leukemia stem cells, which were identified in mice in our lab (Hu Y, Swerdlow S, Duffy TM, Weinmann R, Lee FY, Li S. 2006. Targeting multiple kinase pathways in leukemic progenitors and stem cells is es

ORGANISM(S): Mus musculus

SUBMITTER: Shaoguang Li 

PROVIDER: E-GEOD-10912 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress