Dataset Information
Transcription profiling of rat dentate gyrus samples following passive avoidance learning
Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Niamh O'Sullivan
PROVIDER: E-GEOD-1095 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Temporal change in gene expression in the rat dentate gyrus following passive avoidance learning.
Journal of neurochemistry 20070209 4
A learning event initiates a cascade of altered gene expression leading to synaptic remodelling within the hippocampal dentate gyrus, a structure vital to memory formation. To illuminate this transcriptional program of synaptic plasticity we used microarrays to quantify mRNA from the rat dentate gyrus at increasing times following passive avoidance learning. Approximately, 500 known genes were transcriptionally regulated across the 24 h post-training period. The 0-2 h period saw up-regulation of ...[more]
