Transcription profiling of mouse lung adenocarcinomas of c-Myc-transgenics

ABSTRACT: The transcriptional regulator c-Myc is the most frequently deregulated oncogene in human tumors. Targeted overexpression of this gene in mice results in distinct types of lung adenocarcinomas. By using microarray technology, alterations in the expression of genes were captured based on a female transgenic mouse model in which, indeed, c-Myc overexpression in alveolar epithelium results in the development of bronchiolo-alveolar carcinoma (BAC) and papillary adenocarcinoma (PLAC). In this study, we analyzed exclusively the promoters of induced genes by different in silico methods in order to elucidate the c-Myc transcriptional regulatory network. Experiment Overall Design: For gene expression analysis, RNA was isolated from lung tissue of either 16 c-Myc-transgenic or 16 non-transgenic contr

ORGANISM(S): Mus musculus

SUBMITTER: Jürgen Borlak 

PROVIDER: E-GEOD-10954 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress