Gene expression changes in Drosophila head secondary to levetiracetam treatment during Pentylenetetrazole withdrawal.

ABSTRACT: Drosophila melanogaster adult flies fed on normal food (NF) containing 16 mg/ml of pentylenetetrazole (PTZ) in the food show a hyperkinetic behavior within 24 hours. Half of that concentration, i.e., 8 mg/ml, of the PTZ, if fed for seven days, though doesn’t cause seizure-like behavior, results in a decreased climbing speed in flies. This change in locomotor behavior is progressive and becomes significant only on seventh day of the treatment. This climbing deficit is ameliorated when flies are treated concomitantly with PTZ and either of the two antiepileptic drugs (AEDs), sodium valproate (NaVP) or levetiracetam (LEV). Further experiments based on different regimes of combination and singular PTZ treatment demonstrated that whereas NaVP show a weaker prophylactic and stronger symptomatic

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Abhay Sharma 

PROVIDER: E-GEOD-10988 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress