Transcription profiling of mouse lung from animals exposed to arsenic

ABSTRACT: Exposure to high levels of arsenic in drinking water is associated with several types of cancers including lung, bladder and skin, as well as vascular disease and diabetes. Drinking water standards are based primarily on epidemiology and extrapolation from higher dose experiments, rather than measurements of phenotypic changes associated with chronic exposure to levels of arsenic similar to the current standard of 10ppb, and little is known about the difference between arsenic in food as opposed to arsenic in water. Measurement of phenotypic changes at low doses may be confounded by the effect of laboratory diet, in part because of trace amounts of arsenic in standard laboratory chows, but also because of broad metabolic changes in response to the chow itself. Finally, this series contrast

ORGANISM(S): Mus musculus

SUBMITTER: Joshua Hamilton 

PROVIDER: E-GEOD-11056 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress