A DNA polymerase ? accessory protein, Mcl1, is required for propagation of centromere structures in fission yeast
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ABSTRACT:
ORGANISM(S): Schizosaccharomyces pombe
SUBMITTER: Katsuhiko Shirahige
PROVIDER: E-GEOD-11102 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
A DNA polymerase alpha accessory protein, Mcl1, is required for propagation of centromere structures in fission yeast.
Natsume Toyoaki T Tsutsui Yasuhiro Y Sutani Takashi T Dunleavy Elaine M EM Pidoux Alison L AL Iwasaki Hiroshi H Shirahige Katsuhiko K Allshire Robin C RC Yamao Fumiaki F
PloS one 20080521 5
Specialized chromatin exists at centromeres and must be precisely transmitted during DNA replication. The mechanisms involved in the propagation of these structures remain elusive. Fission yeast centromeres are composed of two chromatin domains: the central CENP-A(Cnp1) kinetochore domain and flanking heterochromatin domains. Here we show that fission yeast Mcl1, a DNA polymerase alpha (Pol alpha) accessory protein, is critical for maintenance of centromeric chromatin. In a screen for mutants th ...[more]
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