Comparative genomic hybridization of human primary melanomas

ABSTRACT: Malignant melanoma is an aggressive heterogeneous disease for which new biomarkers for diagnosis and clinical outcome are needed. We investigated by array-CGH the presence of DNA gains and losses to provide better genomic profile of primary malignant melanoma and to explore the possibility to distinguish metastatic from non metastatic melanomas using this technology. High resolution array-CGH (Agilent Technologies, Palo Alto, CA), with more than 40.000 probes, has been used to analyze 20 frozen tissues of vertical growth phase primary melanoma with a minimum follow-up time of 36 months. Eight patients developed nodal metastatic disease and twelve did not. For results validation, 83 additional melanoma samples with similar clinical characteristics were analysed by FISH. DNA copy number aber

ORGANISM(S): Homo sapiens

SUBMITTER: Juan Cigudosa 

PROVIDER: E-GEOD-11109 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress