ISR target genes in the liver of mock-injected and AP20187-treated mice of wildtype and Atf4-/- genotype

ABSTRACT: The molecular mechanisms linking the stress of unfolded proteins in the endoplasmic reticulum (ER stress) to glucose intolerance in obese animals are poorly understood. In this study enforced expression of a translation initiation 2α (eIF2α)-specific phosphatase, GADD34, was used to selectively compromise signaling in the eIF2(αP)-dependent arm of the ER unfolded protein response in liver of transgenic mice. The transgene resulted in lower liver glycogen levels and susceptibility to fasting hypoglycemia in lean mice and glucose tolerance and diminished hepato-steatosis in animals fed a high fat diet. Attenuated eIF2(αP) correlated with lower expression of the adipogenic nuclear receptor PPARγ and its upstream regulators, the transcription factors C/EBPα and C/EBPβ, in transgenic mouse live

ORGANISM(S): Mus musculus

SUBMITTER: Seiichi Oyadomari 

PROVIDER: E-GEOD-11116 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress