Transcription profiling of mouse liver after 4.5 days of repeated combined acoustic and restraint stress vs. control

ABSTRACT: Stress is a powerful modulator of neuroendocrine, behavioral and immunological functions. After 4.5 days of repeated combined acoustic and restraint stress as a murine model of chronic psychological stress severe metabolic dysregulations became detectable in female BALB/c mice. Stress-induced alterations of metabolic processes that were found in a hepatic mRNA expression profiling were verified by in vivo analyses. Repeatedly stressed mice developed a hypermetabolic syndrome with severe loss of lean body mass, hyperglycemia, dyslipidemia, increased amino acid turn-over, and acidosis. This was associated with hypercortisolism, hyperleptinemia, insulin resistance, and hypothyroidism. In contrast, after a single acute stress exposure changes in expression of metabolic genes were much less pro

ORGANISM(S): Mus musculus

SUBMITTER: Maren Depke 

PROVIDER: E-GEOD-11125 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress