Transcription profiling of mouse FVB/N wild type and transgenic Tg.AC mice to examine skin papilloma development

ABSTRACT: This study analyzes gene expression associated with papilloma development in Tg.AC v-Ha-ras transgenic mice and identifies novel genes and biological processes that may be critical to skin carcinogenesis in these mice. Epidermal abrasion was used to synchronously induce epidermal regeneration in FVB/N wild type and transgenic Tg.AC mice. Skin papillomagenesis was uniquely induced in Tg.AC mice, and gene expression profiling was carried out using a 22,000 element mouse DNA microarray. Histological analysis showed that papillomas developed at a high rate by day 30 after abrasion in transgenic animals, while no papilloma developed in wild type mice. Transgene specific differentially expressed genes were identified at day 30 post-abrasion and these genes were annotated using EASE software

ORGANISM(S): Mus musculus

SUBMITTER: Hong Dang 

PROVIDER: E-GEOD-11136 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress