Transcription profiling of Xenopus animal cap explants to investigate neural fate stabilization

ABSTRACT: The goal of the current NS23158 funding is to understand how neural fate-stabilizing (NFS) genes function in order to provide fundamental knowledge about their potential roles in neural stem cell development. Neural fate-stabilization is characterized by the expansion of the neural plate shortly after the presumptive neural ectoderm has been induced by the repression BMP signaling. During this time period a number of early-expressed NFS genes are expressed, each of which expands the neural plate in gain-of-function assays. But, we do not know how these genes are related to one another or whether they are arranged in a linear gene pathway or multi-path hierarchy. A key aim of this grant is to elucidate the relationship of foxD5, an early-expressed NFS gene that we cloned, to other NFS-g

ORGANISM(S): Xenopus laevis

SUBMITTER: Elizabeth Salomon 

PROVIDER: E-GEOD-11143 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress