Transcription profiling of human chronic hepatitis C paired liver biopsies before and after pegINF-alpha treament

ABSTRACT: Hepatitis C virus (HCV) infection is a major cause of chronic liver disease worldwide. The current standard therapy for chronic hepatitis C (CHC) consists of a combination of pegylated IFN alpha (pegIFN-alpha) and ribavirin. It achieves a sustained viral clearance in only 50â??60% of patients. To learn more about molecular mechanisms underlying treatment failure, we investigated IFN-induced signaling in paired liver biopsies collected from CHC patients before and after administration of pegIFN-alpha. In patients with a rapid virological response to treatment, pegIFN-alpha induced a strong up-regulation of IFN-stimulated genes (ISGs). As shown previously, nonresponders had high expression levels of ISGs before therapy. Analysis of posttreatment biopsies of these patients revealed that pegIF

ORGANISM(S): Homo sapiens

SUBMITTER: Edward James Oakeley 

PROVIDER: E-GEOD-11190 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress