Fibrotic Myofibroblasts Manifest Genome-Wide Derangements of Translational Control

ABSTRACT: As a group, fibroproliferative disorders of the lung, liver, kidney, heart, vasculature and integument are common, progressive and refractory to therapy. They can emerge following toxic insults, but are frequently idiopathic. Their enigmatic propensity to resist therapy and progress to organ failure has focused attention on the myofibroblast – the primary effector of the fibroproliferative response. A central unanswered question is whether these myofibroblasts have acquired a distinct pathological phenotype - or whether they are normal myofibroblasts with a pathological phenotype that depends upon residing in a sea of pro-fibrotic cytokines and an abnormal extracellular matrix. Using a systems approach to study this question in a prototype fibrotic disease, Idiopathic Pulmonary Fibrosis (I

ORGANISM(S): Homo sapiens

SUBMITTER: Ola Larsson 

PROVIDER: E-GEOD-11196 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress