Ontology highlight
ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Michael Smerdon
PROVIDER: E-GEOD-11282 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Nag Ronita R Gong Feng F Fahy Deirdre D Smerdon Michael J MJ
Nucleic acids research 20080528 11
Single amino acid changes at specific DNA contacts of histones H3 and H4 generate SWI/SNF-independent (Sin) mutants in yeast. We have analyzed the effect of the Sin mutation at R45 of histone H4 on cell survival following UV irradiation, nucleotide excision repair (NER) and chromatin structure. We find that this mutation renders yeast cells more resistant to UV damage and enhances NER at specific chromatin loci. In the transcriptionally silent HML, repressed GAL10 and the constitutively active R ...[more]