Transcription profiling by array of human APECED patients in vitro monocyte-differentiated dendritic cells vs. healthy controls

ABSTRACT: Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a monogenic autoimmune disease caused by mutations in the AIRE gene. AIRE functions as a transcriptional regulator and it has a central role in the development of immunological tolerance. AIRE regulates the expression of ectopic antigens in epithelial cells of the thymic medulla and has been shown to participate in the development of peripheral tolerance. However, the mechanism of action of AIRE has remained elusive. To further investigate the role of AIRE in host immune functions, using microarray technology, we studied the properties and transcript profiles in in vitro monocyte-differentiated dendritic cells (moDCs) obtained from APECED patients and healthy controls. Experiment Overall Design: This study includes

ORGANISM(S): Homo sapiens

SUBMITTER: Niko Kristian Sillanpaa 

PROVIDER: E-GEOD-11309 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress