Drosophila Sex Hierarchy Regulated Gene Expression in 48 hour APF Pupae

ABSTRACT: Drosophila melanogaster undergoes a complete metamorphosis, during which time the larval male and female forms transition into sexually dimorphic, reproductive adult forms. To understand this complex morphogenetic process at a molecular-genetic level, we performed whole genome microarray analyses. In somatic tissues at 48 hour After Puparium Formation (APF), 173 sex-biased transcripts that likely function downstream of the doublesex (dsx) branch of the sex determination hierarchy were identified. The mode of regulation of the sex-specific isoforms of DSX (DSX-F and DSX-M) was examined. It was determined that for most downstream targets, DSX-F and DSX-M regulate gene expression in the same manner, but that one isoform acts as a more potent regulator. Keywords: wild type; genetic modifi

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Matthew Lebo 

PROVIDER: E-GEOD-11311 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress